Reactome | Kcnn2 transports K+ from the cytosol to the extracellular region

Kcnn2 transports K+ from the cytosol to the extracellular region

Stable Identifier

R-MMU-9663768

Type

Reaction [transition]

Species

Mus musculus

Compartment

plasma membrane

ReviewStatus

5/5

General

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Kcnn2 transports K+ from the cytosol to the extracellular region

Small potassium current channels (SK2 channels, Kcnn2 tetramers) in outer hair cells (OHCs) open in response to cytosolic calcium and transport potassium ions from the cytosol to the extracellular region, resulting in hyperpolarization and inhibition of contraction of the OHC (Kong et al. 2008, Maison et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
18818242	Expression of the SK2 calcium-activated potassium channel is required for cholinergic function in mouse cochlear hair cells Kong, JH, Adelman, JP, Fuchs, PA	J. Physiol. (Lond.)	2008
23282326	Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea Maison, SF, Pyott, SJ, Meredith, AL, Liberman, MC	J. Neurophysiol.	2013