Reactome | p-T-Eif2ak1 phosphorylates Eif2s1 (eIF2-alpha)

p-T-Eif2ak1 phosphorylates Eif2s1 (eIF2-alpha)

Stable Identifier

R-MMU-9655565

Type

Reaction [transition]

Species

Mus musculus

Compartment

cytosol

ReviewStatus

5/5

General

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p-T-Eif2ak1 phosphorylates Eif2s1 (eIF2-alpha)

Phosphorylated Eif2ak1 phosphorylates Eif2s1 (eIF2-alpha) on serine-52 (homologous to serine-51 of the rabbit homolog) (Lu et al. 2001, Rafie-Kolpin et al. 2003, Igarashi et al. 2011). Phosphothreonine-485 of Eik2ak1 is required for kinase activity of Eif2ak1 acting on Eif2s1 (Rafie-Kolpin et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
21223507	Autophosphorylation of heme-regulated eukaryotic initiation factor 2α kinase and the role of the modification in catalysis Shimizu, T, Kobayashi, N, Igarashi, J, Matsushita, M, Yoshioka, S, Sasaki, T	FEBS J.	2011
12767237	Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI Han, AP, Rafie-Kolpin, M, Chen, JJ	Biochemistry	2003
11689689	Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses Han, AP, Lu, L, Chen, JJ	Mol. Cell. Biol.	2001

Participants

Input

Output

Orthologous Events

p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) (Homo sapiens)

Authored

May, B (2019-07-24)

Reviewed

Chen, JJ (2019-10-22)

Created

May, B (2019-07-24)

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