Transcription of Ddit3

Stable Identifier
R-MMU-9655072
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Transcription of Ddit3
The Ddit3 gene is transcribed to yield mRNA (Harding et al. 2000, Harding et al. 2003, Zhang et al. 2019). Transcription of Ddit3 is activated by Atf4 in response to certain stresses (Harding et al. 2000, Harding et al. 2003), including heme deficiency, which acts via the integrated stress kinase Eif2ak1 (HRI) (Zhang et al. 2019).
Literature References
PubMed ID Title Journal Year
31033440 HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

Macias-Garcia, A, Zhang, S, Butty, VL, Levine, SS, Sankaran, VG, Velazquez, J, Ulirsch, JC, Chen, JJ

Elife 2019
11106749 Regulated translation initiation controls stress-induced gene expression in mammalian cells

Zhang, Y, Harding, HP, Schapira, M, Wek, R, Zeng, H, Ron, D, Novoa, I

Mol. Cell 2000
12667446 An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

Ron, D, Zhang, Y, Yun, C, Zeng, H, Stojdl, DF, Popko, B, Lu, PD, Novoa, I, Calfon, M, Hettmann, T, Paules, R, Sadri, N, Harding, HP, Leiden, JM, Bell, JC

Mol. Cell 2003
Participants
Input
Output
This event is regulated
Positively by
Regulator
Atf4:Ddit3 gene [nucleoplasm] (Mus musculus)
Orthologous Events
Transcription of DDIT3 (CHOP, GADD153) in response to heme deficiency (Homo sapiens)
Authored
May, B  (2019-07-22)
Reviewed
Chen, JJ  (2019-10-22)
Created
May, B  (2019-07-23)
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