Transcription of Ddit3

Stable Identifier
Reaction [omitted]
Mus musculus
SVG |   | PPTX  | SBGN
Transcription of Ddit3

The Ddit3 gene is transcribed to yield mRNA (Harding et al. 2000, Harding et al. 2003, Zhang et al. 2019). Transcription of Ddit3 is activated by Atf4 in response to certain stresses (Harding et al. 2000, Harding et al. 2003), including heme deficiency, which acts via the integrated stress kinase Eif2ak1 (HRI) (Zhang et al. 2019).

Literature References
PubMed ID Title Journal Year
11106749 Regulated translation initiation controls stress-induced gene expression in mammalian cells

Harding, HP, Novoa, I, Zhang, Y, Zeng, H, Wek, R, Schapira, M, Ron, D

Mol. Cell 2000
31033440 HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

Zhang, S, Macias-Garcia, A, Ulirsch, JC, Velazquez, J, Butty, VL, Levine, SS, Sankaran, VG, Chen, JJ

Elife 2019
12667446 An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

Harding, HP, Zhang, Y, Zeng, H, Novoa, I, Lu, PD, Calfon, M, Sadri, N, Yun, C, Popko, B, Paules, R, Stojdl, DF, Bell, JC, Hettmann, T, Leiden, JM, Ron, D

Mol. Cell 2003
This event is regulated
Orthologous Events
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