Expression of Grb10

Stable Identifier
R-MMU-9654806
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Expression of Grb10

The Grb10 gene is transcribed to yield mRNA and the mRNA is translated to yield Grb10 protein (Luo et al. 2018, Zhang et al. 2019). Expression of Grb10 is activated by Atf4 in response to endoplasmic reticulum stress (Luo et al. 2018) and heme deficiency (Zhang et al. 2019).

Literature References
PubMed ID Title Journal Year
31033440 HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

Macias-Garcia, A, Zhang, S, Butty, VL, Levine, SS, Sankaran, VG, Velazquez, J, Ulirsch, JC, Chen, JJ

Elife 2019
29555819 De-silencing Grb10 contributes to acute ER stress-induced steatosis in mouse liver

Xu, Z, Liu, B, Liu, F, Tang, P, Liu, H, Xiao, B, Luo, L, Jiang, W, Bu, J, Luo, H, Zhou, Z, Du, C

J. Mol. Endocrinol. 2018
Participants
This event is regulated
Positively by
Regulator
Summation

Atf4 binds the promoter of the ATF3 gene, resulting in enhanced transcription (Jiang et al. 2004).

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