Atf4 binds the Ppp1r15a (Gadd34) promoter

Stable Identifier
R-MMU-9654760
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Atf4 binds the Ppp1r15a (Gadd34) promoter

Atf4 binds a conserved site in the promoter of the Ppp1r15a (Gadd34) gene in response to endoplasmic reticulum stress (Ma and Hendershot 2003) and traumatic brain injury (Farook et al. 2013). Atf4 can form homodimers and heterodimers with other bZip proteins, however the binding partner of Atf4 at the Ppp1r15a promoter is unknown. Eif2ak1 activates transcription of Ppp1r15a via Atf4 in response to heme deficiency (Zhang et al. 2019).

Literature References
PubMed ID Title Journal Year
31033440 HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

Zhang, S, Macias-Garcia, A, Ulirsch, JC, Velazquez, J, Butty, VL, Levine, SS, Sankaran, VG, Chen, JJ

Elife 2019
23907468 GADD34 induces cell death through inactivation of Akt following traumatic brain injury

Farook, JM, Shields, J, Tawfik, A, Markand, S, Sen, T, Smith, SB, Brann, D, Dhandapani, KM, Sen, N

Cell Death Dis 2013
12840028 Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress

Ma, Y, Hendershot, LM

J. Biol. Chem. 2003
Participants
Orthologous Events
Authored
Reviewed
Created