Translation of Ddit3

Stable Identifier
R-MMU-9653771
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Translation of Ddit3

The Ddit3 mRNA is translated to yield Ddit3 (CHOP) protein (Palam et al. 2011, Young et al. 2016, Zhang et al. 2019), which is then imported into the nucleus. The mRNA of Ddit3 contains an upstream ORF (uORF) which has a start codon in an unfavorable context (Palam et al. 2011), resulting in low expression of the downstream Ddit3 coding region. When Eif2s1 (Eif2-alpha) is phosphorylated in response to stress, translation of the uORF is suppressed and translation of Ddit3 is increased (Palam et al. 2011, Young et al. 2016, Zhang et al. 2019).

Literature References
PubMed ID Title Journal Year
26817837 Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response

Young, SK, Palam, LR, Wu, C, Sachs, MS, Wek, RC

J. Biol. Chem. 2016
31033440 HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

Zhang, S, Macias-Garcia, A, Ulirsch, JC, Velazquez, J, Butty, VL, Levine, SS, Sankaran, VG, Chen, JJ

Elife 2019
21285359 Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation

Palam, LR, Baird, TD, Wek, RC

J. Biol. Chem. 2011
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