Atf4 and a Cebp protein bind the Atf5 gene

Stable Identifier
R-MMU-9653747
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Atf4 and a Cebp protein bind the Atf5 gene

Atf4 and a member of the CEBP family of transcription factors bind as a heterodimer to a composite CEBP-ATF element in the promoter of the Atf5 gene (Teske et al. 2013, Huggins et al. 2015). CEBP transcription factors that have been shown to interact with ATF4 at the ATF5 promoter are CEBPB (Huggins et al. 2015), CEBPG (Huggins et al. 2015), and DDIT3 (CHOP, Teske et al. 2013).

Literature References
PubMed ID Title Journal Year
23761072 CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

Teske, BF, Fusakio, ME, Zhou, D, Shan, J, McClintick, JN, Kilberg, MS, Wek, RC

Mol. Biol. Cell 2013
26667036 C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4

Huggins, CJ, Mayekar, MK, Martin, N, Saylor, KL, Gonit, M, Jailwala, P, Kasoji, M, Haines, DC, Quiñones, OA, Johnson, PF

Mol. Cell. Biol. 2015
Participants
Orthologous Events
Authored
Reviewed
Created