Atf4 and a Cebp protein bind the Atf5 gene

Stable Identifier
Reaction [binding]
Mus musculus
SVG |   | PPTX  | SBGN
Atf4 and a Cebp protein bind the Atf5 gene

Atf4 and a member of the CEBP family of transcription factors bind as a heterodimer to a composite CEBP-ATF element in the promoter of the Atf5 gene (Teske et al. 2013, Huggins et al. 2015). CEBP transcription factors that have been shown to interact with ATF4 at the ATF5 promoter are CEBPB (Huggins et al. 2015), CEBPG (Huggins et al. 2015), and DDIT3 (CHOP, Teske et al. 2013).

Literature References
PubMed ID Title Journal Year
26667036 C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4

Haines, DC, Jailwala, P, Saylor, KL, Huggins, CJ, Quiñones, OA, Johnson, PF, Martin, N, Kasoji, M, Gonit, M, Mayekar, MK

Mol. Cell. Biol. 2015
23761072 CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

Zhou, D, Teske, BF, Shan, J, McClintick, JN, Wek, RC, Kilberg, MS, Fusakio, ME

Mol. Biol. Cell 2013
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