Transcription of Atf5

Stable Identifier
R-MMU-9653714
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Transcription of Atf5
The Atf5 gene is transcribed to yield mRNA. Transcription of Atf5 is activated by a heterodimer of Atf4 and a Cebp factor in response to proteasome inhibition (Teske et al. 2013), heme deficiency (Zhang et al. 2019), endoplasmic reticulum stress, and amino acid deficiency (Huggins et al. 2015).
Literature References
PubMed ID Title Journal Year
31033440 HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

Macias-Garcia, A, Zhang, S, Butty, VL, Levine, SS, Sankaran, VG, Velazquez, J, Ulirsch, JC, Chen, JJ

Elife 2019
26667036 C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4

Haines, DC, Jailwala, P, Saylor, KL, Huggins, CJ, Quiñones, OA, Johnson, PF, Martin, N, Kasoji, M, Gonit, M, Mayekar, MK

Mol. Cell. Biol. 2015
23761072 CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

Zhou, D, Teske, BF, Shan, J, McClintick, JN, Wek, RC, Kilberg, MS, Fusakio, ME

Mol. Biol. Cell 2013
Participants
Input
Output
This event is regulated
Positively by
Regulator
Atf4:Cebpb,Cebpg,Ddit3:Atf5 gene [nucleoplasm] (Mus musculus)
Orthologous Events
Transcription of ATF5 (Homo sapiens)
Authored
May, B  (2019-07-14)
Reviewed
Chen, JJ  (2019-10-22)
Created
May, B  (2019-07-15)
Cite Us!