PolyUb-Misfolded Proteins:Hdac6 dissociate from complex

Stable Identifier
R-MMU-9646359
Type
Reaction [dissociation]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PolyUb-Misfolded Proteins:Hdac6 dissociate from complex
Misfolded proteins are poly-ubiquitinated and bind a complex comprising of Transitional endoplasmic reticulum ATPase (Vcp), Histone deacetylase 6 (Hdac6), Heat shock protein HSP 90 (Hsp90) and Heat shock factor protein 1 (Hsf1). This binding causes the dissociation of the complex resulting in Hdac6 bound-ubiquitinated proteins and a complex of Hsp90:Hsf1 (Boyault C et al. 2007).
Literature References
PubMed ID Title Journal Year
17785525 HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates

Garrido, C, Gilquin, B, Zhang, Y, Khochbin, S, Vourc'h, C, Matthias, P, Yao, TP, Fritah, S, Kwon, SH, Caron, C, Boyault, C

Genes Dev. 2007
Participants
Input
Output
Orthologous Events
PolyUb-Misfolded Proteins:HDAC6 dissociate from complex (Homo sapiens)
Authored
Varusai, TM  (2019-05-07)
Reviewed
Metzakopian, E  (2019-05-24)
Created
Varusai, TM  (2019-05-23)
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