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ALPK1 [cytosol]
Stable Identifier
R-MMU-9645473
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q9CXB8
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Alpha-protein kinase 1 signaling pathway (Mus musculus)
ALPK1 binds ADP-heptose (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
ALPK1 phosphorylates TIFA (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
ALPK1:ADP-heptose:TIFA dimer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA dimer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
ALPK1:ADP-heptose binds TIFA (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
ALPK1:ADP-heptose:TIFA dimer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
TIFA oligomerization (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA dimer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
ALPK1:ADP heptose [cytosol] (Mus musculus)
ALPK1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9CXB8
Reference Genes
ENSEMBL:ENSMUSG00000028028
Participates
as an input of
ALPK1 binds ADP-heptose (Mus musculus)
as a component of
ALPK1:ADP heptose [cytosol] (Mus musculus)
Inferred From
ALPK1 [cytosol]
(Homo sapiens)
Cross References
PRO
Q9CXB8
MGI
1918731
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