Misfolded proteins translocate from cilium to cytosol

Stable Identifier
R-MMU-9640117
Type
Reaction [transition]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Misfolded proteins translocate from cilium to cytosol
Cellular stress factors damage several cilia proteins and result in their misfolding. These misfolded proteins are translocated into the cytosol of the cell where they are ubiquitinated and eliminated (Lam HC et al. 2013).
Literature References
PubMed ID Title Journal Year
24200693 Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction

Sathirapongsasuti, JF, Ryter, SW, Cervo, M, Lam, HC, Shan, B, Cloonan, SM, Mizumura, K, Mahmood, A, Singh, A, Haspel, JA, Chung, AL, Haley, KJ, Franks, JM, Tesfaigzi, Y, Washko, GR, Yao, H, Bhashyam, AR, Biswal, SS, An, CH, Kim, HP, Owen, CA, Choi, AM, Silverman, EK, Quackenbush, J, Rahman, I

J. Clin. Invest. 2013
Participants
Orthologous Events
Authored
Reviewed
Created
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