Il6ra gene expression is enhanced by Cebpa

Stable Identifier
R-MMU-9634444
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Il6ra gene expression is enhanced by Cebpa

Cebpa activates transcription of the Il6ra gene, which encodes the receptor for Il6 (interleukin-6, IL-6) (Zhang et al. 1998). Mice lacking Cebpa fail to upregulate Il6ra and Csf3r (G-CSFR) and fail to produce granulocytes (Zhang et al. 1998). The defect can be rescued by addition of soluble Il6ra plus Il6 or by addition of Csf3r.

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This event is regulated
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Orthologous Events
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