Cebpa activates transcription of the Il6ra gene, which encodes the receptor for Il6 (interleukin-6, IL-6) (Zhang et al. 1998). Mice lacking Cebpa fail to upregulate Il6ra and Csf3r (G-CSFR) and fail to produce granulocytes (Zhang et al. 1998). The defect can be rescued by addition of soluble Il6ra plus Il6 or by addition of Csf3r.
Zhang, P, Iwama, A, Datta, MW, Darlington, GJ, Link, DC, Tenen, DG
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