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Il6ra gene expression is enhanced by Cebpa
Stable Identifier
R-MMU-9634444
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
,
cytosol
ReviewStatus
5/5
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
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PPTX
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SBGN
Cebpa activates transcription of the Il6ra gene, which encodes the receptor for Il6 (interleukin-6, IL-6) (Zhang et al. 1998). Mice lacking Cebpa fail to upregulate Il6ra and Csf3r (G-CSFR) and fail to produce granulocytes (Zhang et al. 1998). The defect can be rescued by addition of soluble Il6ra plus Il6 or by addition of Csf3r.
Literature References
PubMed ID
Title
Journal
Year
9743535
Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis
Datta, MW
,
Zhang, P
,
Tenen, DG
,
Darlington, GJ
,
Iwama, A
,
Link, DC
J. Exp. Med.
1998
Participants
Input
Il6ra gene [nucleoplasm]
(Mus musculus)
Output
Il6ra [plasma membrane]
(Mus musculus)
This event is regulated
Positively by
Regulator
Cebpa [nucleoplasm]
(Mus musculus)
Orthologous Events
IL6R gene expression is enhanced by CEBPA (Homo sapiens)
Authored
May, B (2018-09-22)
Reviewed
Skokowa, J (2019-03-10)
Created
May, B (2019-01-11)
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