Cebpa activates transcription of the Il6ra gene, which encodes the receptor for Il6 (interleukin-6, IL-6) (Zhang et al. 1998). Mice lacking Cebpa fail to upregulate Il6ra and Csf3r (G-CSFR) and fail to produce granulocytes (Zhang et al. 1998). The defect can be rescued by addition of soluble Il6ra plus Il6 or by addition of Csf3r.