Reactome | Il6ra gene expression is enhanced by Cebpa

Il6ra gene expression is enhanced by Cebpa

Stable Identifier

R-MMU-9634444

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

General

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Il6ra gene expression is enhanced by Cebpa

Cebpa activates transcription of the Il6ra gene, which encodes the receptor for Il6 (interleukin-6, IL-6) (Zhang et al. 1998). Mice lacking Cebpa fail to upregulate Il6ra and Csf3r (G-CSFR) and fail to produce granulocytes (Zhang et al. 1998). The defect can be rescued by addition of soluble Il6ra plus Il6 or by addition of Csf3r.

Literature References

PubMed ID	Title	Journal	Year
9743535	Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis Datta, MW, Zhang, P, Tenen, DG, Darlington, GJ, Iwama, A, Link, DC	J. Exp. Med.	1998

Participants

Input

Il6ra gene [nucleoplasm] (Mus musculus)

Output

Il6ra [plasma membrane] (Mus musculus)

This event is regulated

Positively by

Regulator

Cebpa [nucleoplasm] (Mus musculus)

Orthologous Events

IL6R gene expression is enhanced by CEBPA (Homo sapiens)

Authored

May, B (2018-09-22)

Reviewed

Skokowa, J (2019-03-10)

Created

May, B (2019-01-11)

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