Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Eif2s1 [cytosol]
Stable Identifier
R-MMU-9633482
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Eukaryotic translation initiation factor 2 subunit 1, IF2A_MOUSE
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to mitochondrial stress (Mus musculus)
DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
Unfolded Protein Response (UPR) (Mus musculus)
PERK regulates gene expression (Mus musculus)
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Translation (Mus musculus)
Eukaryotic Translation Initiation (Mus musculus)
Cap-dependent Translation Initiation (Mus musculus)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Mus musculus)
Translation initiation complex formation (Mus musculus)
Formation of translation initiation complexes containing mRNA that does not circularize (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
48S complex [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
Formation of the ternary complex, and subsequently, the 43S complex (Mus musculus)
De novo formation of eIF2:GTP (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
Formation of the 43S pre-initiation complex (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
Met-tRNAi binds to eIF2:GTP to form the ternary complex (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
GTP hydrolysis and joining of the 60S ribosomal subunit (Mus musculus)
eIF2:GTP is hydrolyzed, eIFs are released (Mus musculus)
48S complex [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
eIF2:GDP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
Recycling of eIF2:GDP (Mus musculus)
Formation of eIF2:GDP:eIF2B intermediate (Mus musculus)
eIF2:GDP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
eIF2:GDP: eIF2B [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
eIF2 activation (Mus musculus)
eIF2:GDP: eIF2B [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
Ribosomal scanning and start codon recognition (Mus musculus)
Ribosomal scanning (Mus musculus)
48S complex [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
Start codon recognition (Mus musculus)
48S complex [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
L13a-mediated translational silencing of Ceruloplasmin expression (Mus musculus)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Mus musculus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Mus musculus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
Transport of small molecules (Mus musculus)
ABC-family proteins mediated transport (Mus musculus)
ABCF1 binds EIF2 (Mus musculus)
ABCF1:EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q6ZWX6 Eif2s1
Gene Names
Eif2s1, Eif2a
Chain
chain:1-315
Reference Genes
BioGPS Gene:13665 Eif2s1
ENSEMBL:ENSMUSG00000021116.11 Eif2s1
KEGG Gene (Mus musculus):13665 Eif2s1
Monarch:13665 Eif2s1
NCBI Gene:13665 Eif2s1
UCSC:Q6ZWX6 Eif2s1
Reference Transcript
RefSeq:NM_026114.3 Eif2s1
Other Identifiers
10396795
13665
1420491_at
1440272_at
1452662_a_at
166055_r_at
166714_at
17276732
4396460
4650558
4750004
4782166
4807834
4824645
4919566
5068903
5225976
5349701
5386830
5438597
5446435
5465633
5469409
5476547
5485985
5513990
5539871
5544600
5586857
5598179
5615369
94253_at
A_51_P448334
A_51_P448340
A_52_P440508
A_55_P2184811
A_55_P2184816
GE122085
GE42291
GO:0003676
GO:0003723
GO:0003743
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005850
GO:0006412
GO:0006413
GO:0006417
GO:0010494
GO:0012501
GO:0023052
GO:0032057
GO:0033290
GO:0034063
GO:0034198
GO:0034599
GO:0034605
GO:0034644
GO:0034976
GO:0036490
GO:0036499
GO:0043022
GO:0043226
GO:0043558
GO:0044207
GO:0045182
GO:0045202
GO:0097451
GO:1904373
GO:1990737
GO:2000676
ILMN_1255468
ILMN_2696159
Msa.15713.0_s_at
Msa.39021.0_f_at
aa408104_rc_s_at
mMC004098
mMR027112
Participates
as an input of
p-T-Eif2ak1 phosphorylates Eif2s1 (eIF2-alpha) (Mus musculus)
as a component of
Eif2s1:Eif2s2:Eif2s3 [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Other forms of this molecule
p-S52-Eif2s1 [cytosol]
Inferred From
EIF2S1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_080390.1
Ensembl
ENSMUST00000071230
,
ENSMUSP00000071214
,
ENSMUSG00000021116
PRO
Q6ZWX6
MGI
95299
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text