Substrate translocates into late endosomal lumen

Stable Identifier
R-MMU-9631080
Type
Reaction
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Substrate translocates into late endosomal lumen

In addition to bulk protein degradation, Microautophagy (MI) can also target KFERQ motif protein substrates similar to Chaperone Mediated Autophagy (CMA). However, MI is distinct from CMA in that it occurs during late endosomes/multivesicular bodies formation. Upon binding with Hspa8, substrates are transported from the cytosol to late endosomes. Hspa8 binds with the phospholipids on the late endosomal membrane. Subsequently, the substrate is transported into the lumen via endosomal sorting complexes required for transport (ESCRTI and ESCRTIII systems) (Sahu R et al. 2011). This event is represented as a black box since the precise molecular mechanism of the substrate transport into the endosomal lumen is unclear.

Literature References
PubMed ID Title Journal Year
21238931 Microautophagy of cytosolic proteins by late endosomes

Sahu, R, Kaushik, S, Clement, CC, Cannizzo, ES, Scharf, B, Follenzi, A, Potolicchio, I, Nieves, E, Cuervo, AM, Santambrogio, L

Dev. Cell 2011
Participants
This event is regulated
Orthologous Events
Authored
Reviewed
Created