Hspa8:substrate binds late endosomal phospholipids

Stable Identifier
R-MMU-9631076
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Hspa8:substrate binds late endosomal phospholipids

Microautophagy (MI) can target KFERQ motif containing protein substrates to endosomal degradation. Upon binding with Hspa8, substrates are transported from the cytosol to late endosomes. Here, Hspa8 binds with the phospholipids on the late endosomal membrane. This interaction facilitates the vesicle-mediated transport of Hspa8:substrate complex into the late endosomes for degradation (Sahu R et al. 2011).

Literature References
PubMed ID Title Journal Year
21238931 Microautophagy of cytosolic proteins by late endosomes

Sahu, R, Kaushik, S, Clement, CC, Cannizzo, ES, Scharf, B, Follenzi, A, Potolicchio, I, Nieves, E, Cuervo, AM, Santambrogio, L

Dev. Cell 2011
Participants
Orthologous Events
Authored
Reviewed
Created
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