Neil3 cleaves thymine glycol

Stable Identifier
R-MMU-9629509
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Neil3 cleaves thymine glycol
Mouse Neil3 cleaves oxidatively damaged thymine in the form of thymine glycol with a preference for single-strand DNA (ssDNA) over double-strand DNA (dsDNA) oligomers (Liu et al. 2010, Zhou et al. 2013).
Literature References
PubMed ID Title Journal Year
23926102 Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context

Zhou, J, Liu, M, Fleming, AM, Burrows, CJ, Wallace, SS

J. Biol. Chem. 2013
Participants
Input
Output
Catalyst Activity

DNA N-glycosylase activity of Neil3:Tg-DNA oligomer [nucleoplasm]

Physical Entity
Neil3:Tg-DNA oligomer [nucleoplasm] (Mus musculus)
Activity
DNA N-glycosylase activity (GO:0019104)
Orthologous Events
NEIL3 cleaves thymine glycol (Homo sapiens)
Authored
Orlic-Milacic, M  (2019-01-05)
Reviewed
Zhou, J  (2019-02-11)
Created
Orlic-Milacic, M  (2018-11-21)
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