Sirt1 deacetylates Foxo1

Stable Identifier
R-MMU-9626966
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Sirt1 deacetylates Foxo1
Recombinant mouse Sirt1 deacetylates recombinant mouse Foxo1 (Daitoku et al. 2004).
Literature References
PubMed ID Title Journal Year
15220471 Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

Daitoku, H, Hatta, M, Matsuzaki, H, Aratani, S, Ohshima, T, Miyagishi, M, Nakajima, T, Fukamizu, A

Proc. Natl. Acad. Sci. U.S.A. 2004
Participants
Input
Output
Catalyst Activity

NAD-dependent protein lysine deacetylase activity of Sirt1 [nucleoplasm]

Physical Entity
Sirt1 [nucleoplasm] (Mus musculus)
Activity
NAD-dependent protein lysine deacetylase activity (GO:0034979)
Orthologous Events
SIRT1 deacetylates FOXO1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-31)
Reviewed
Bertaggia, E  (2018-10-26)
Created
Orlic-Milacic, M  (2018-10-30)
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