In mouse liver cells, Foxo6 directly stimulates transcription of the G6pc gene, encoding glucose-6-phosphatase (Kim et al. 2011). G6pc gene transcription is also directly stimulated by the complex of Foxo1 and Pparg1ca (Puigserver et al. 2003).
Kim, DH, Perdomo, G, Zhang, T, Slusher, S, Lee, S, Phillips, BE, Fan, Y, Giannoukakis, N, Gramignoli, R, Strom, S, Ringquist, S, Dong, HH
Puigserver, P, Rhee, J, Donovan, J, Walkey, CJ, Yoon, JC, Oriente, F, Kitamura, Y, Altomonte, J, Dong, H, Accili, D, Spiegelman, BM
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