G6pc gene expression is stimulated by Foxo6

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R-MMU-9623272
Type
Reaction [omitted]
Species
Mus musculus
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General
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G6pc gene expression is stimulated by Foxo6

In mouse liver cells, Foxo6 directly stimulates transcription of the G6pc gene, encoding glucose-6-phosphatase (Kim et al. 2011). G6pc gene transcription is also directly stimulated by the complex of Foxo1 and Pparg1ca (Puigserver et al. 2003).

Literature References
PubMed ID Title Journal Year
21940782 FoxO6 integrates insulin signaling with gluconeogenesis in the liver

Kim, DH, Perdomo, G, Zhang, T, Slusher, S, Lee, S, Phillips, BE, Fan, Y, Giannoukakis, N, Gramignoli, R, Strom, S, Ringquist, S, Dong, HH

Diabetes 2011
12754525 Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

Puigserver, P, Rhee, J, Donovan, J, Walkey, CJ, Yoon, JC, Oriente, F, Kitamura, Y, Altomonte, J, Dong, H, Accili, D, Spiegelman, BM

Nature 2003
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