Cebpb mRNA is translated to yield Cebpb protein

Stable Identifier
R-MMU-9622513
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Cebpb mRNA is translated to yield Cebpb protein

Cytosolic ribosomes translate the Cebpb mRNA to yield Cebpb protein (Calkhoven et al. 2000. Guerzoni et al. 2006, Basu et al. 2011, Perino et al. 2014), which is then imported into the nucleus. Translation initiation at 3 different methionine codons produces 3 different isoforms: CEBPB-FL, CEBPB-LAP, and CEBPB-LIP (Calkhoven et al. 2000).

Literature References
PubMed ID Title Journal Year
10921906 Translational control of C/EBPalpha and C/EBPbeta isoform expression

Calkhoven, CF, Müller, C, Leutz, A

Genes Dev. 2000
16418324 Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells

Guerzoni, C, Bardini, M, Mariani, SA, Ferrari-Amorotti, G, Neviani, P, Panno, ML, Zhang, Y, Martinez, R, Perrotti, D, Calabretta, B

Blood 2006
25365223 TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

Perino, A, Pols, TW, Nomura, M, Stein, S, Pellicciari, R, Schoonjans, K

J. Clin. Invest. 2014
21804532 3'UTR elements inhibit Ras-induced C/EBPβ post-translational activation and senescence in tumour cells

Basu, SK, Malik, R, Huggins, CJ, Lee, S, Sebastian, T, Sakchaisri, K, Quiñones, OA, Alvord, WG, Johnson, PF

EMBO J. 2011
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