Cebpb gene transcription is enhanced by phospho-Creb1 and phospho-Stat3

Stable Identifier
R-MMU-9617229
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Cebpb gene transcription is enhanced by phospho-Creb1 and phospho-Stat3

During emergency granulopoiesis triggered by bacterial infection, transcription of Cebpb is activated by the cytokines Csf2 (GM-CSF) and Csf3 (G-CSF): Csf2 acts via Csf2r and causes phosphorylation of Creb1 which then binds the promoter of the Cebpb gene (Hirai et al. 2013) while Csf3 acts via Csf3r and causes phosphorylation of Stat3 which also binds the promoter of the Cebpb gene (Zhang et al. 2010). Both phospho-Creb1 and phospho-Stat3 activate transcription of Cebpb (Zhang et al. 2010, Hirai et al. 2013).

Literature References
PubMed ID Title Journal Year
20581311 STAT3 controls myeloid progenitor growth during emergency granulopoiesis

Zhang, H, Nguyen-Jackson, H, Panopoulos, AD, Li, HS, Murray, PJ, Watowich, SS

Blood 2010
23382991 Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein β

Hirai, H, Kamio, N, Huang, G, Matsusue, A, Ogino, S, Kimura, N, Satake, S, Ashihara, E, Imanishi, J, Tenen, DG, Maekawa, T

PLoS ONE 2013
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