Cebpa transcription is enhanced by Runx1, Spi1 (PU.1), Gata2, Tal1 (Scl), Fli1, Myb, and Cebpa

Stable Identifier
R-MMU-9616247
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Cebpa transcription is enhanced by Runx1, Spi1 (PU.1), Gata2, Tal1 (Scl), Fli1, Myb, and Cebpa

Runx1, Spi1 (PU.1), Gata2, Tal1 (Scl), Myb, and Cebpa (Lane et al. 1996) all contribute to the level of transcription in hemopoietic progenitor cells and myeloid progenitor cells (Wilson et al. 2010, Guo et al. 2012, Guo et al. 2014, Cooper et al. 2015). High levels of Cebpa appear to cause granulopoiesis; low levels of Cebpa appear to cause monopoiesis.

Literature References
PubMed ID Title Journal Year
22451420 Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis

Guo, H, Ma, O, Speck, NA, Friedman, AD

Blood 2012
25938608 The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets Factors

Cooper, S, Guo, H, Friedman, AD

PLoS ONE 2015
8680485 Control of adipocyte differentiation by CCAAT/enhancer binding protein alpha (C/EBP alpha)

Lane, MD, Lin, FT, MacDougald, OA, Vasseur-Cognet, M

Int. J. Obes. Relat. Metab. Disord. 1996
20887958 Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators

Wilson, NK, Foster, SD, Wang, X, Knezevic, K, Schütte, J, Kaimakis, P, Chilarska, PM, Kinston, S, Ouwehand, WH, Dzierzak, E, Pimanda, JE, de Bruijn, MF, Göttgens, B

Cell Stem Cell 2010
24868087 The Cebpa +37-kb enhancer directs transgene expression to myeloid progenitors and to long-term hematopoietic stem cells

Guo, H, Ma, O, Friedman, AD

J. Leukoc. Biol. 2014
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