The evolutionarily conserved upstream enhancer of the Cebpa gene binds Runx1 (Guo et al. 2012), Spi1 (PU.1), Gata2, Tal1 (Scl), Fli1, Myb, and Cebpa (Lane et al. 1996) in myeloid progenitor cells (Wilson et al. 2010, Guo et al. 2014, Cooper et al. 2015). Cebpa, Runx1, Gata2, SCL, SPI1, and Fli1 concomitantly bind the Cebpa promoter (Wilson et al. 2010, Cooper et al.2015). Runx1 appears to be required to produce sufficient Cebpa for granulopoiesis, as Cebpa:Cebpa homodimers favor granulopoiesis while monopoiesis is favored by a reduction in Runx1 (Guo et al. 2012) and AP-1:Cebpa heterodimers (Cooper et al. 2015).
Guo, H, Cooper, S, Friedman, AD
Guo, H, Speck, NA, Friedman, AD, Ma, O
Lane, MD, Vasseur-Cognet, M, Lin, FT, MacDougald, OA
Schütte, J, Pimanda, JE, Göttgens, B, Foster, SD, Dzierzak, E, Chilarska, PM, de Bruijn, MF, Ouwehand, WH, Wang, X, Kaimakis, P, Knezevic, K, Kinston, S, Wilson, NK
Guo, H, Friedman, AD, Ma, O
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