Prkaa2 phosphorylates Plins

Stable Identifier
R-MMU-9613545
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Prkaa2 phosphorylates Plins

Lipophagy is the process of autophagic degradation of lipid droplets into fatty acids. Lipid droplets are coated with perilipin (Plin) proteins and they need to be eliminated for the degradation of the lipids inside. Cytosolic Heat shock cognate 71 kDa protein (Hspa8) binds Plin2 and Plin3 on the lipid droplet surface. Subsequently, Prkaa2 binds and phosphorylates perilipins targeting them for lipophagy (S Kaushik et al. 2015, S Kaushik et al. 2016). The precise phosphorylation site(s) on Plins are unknown.

Literature References
Participants
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Ampk-alpha2:Ampk-beta:Ampk-gamma:AMP [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!