Reactome | Prkaa2 phosphorylates Plins

Prkaa2 phosphorylates Plins

Stable Identifier

R-MMU-9613545

Type

Reaction [omitted]

Species

Mus musculus

Compartment

cytosol, lipid droplet

ReviewStatus

5/5

General

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Lipophagy is the process of autophagic degradation of lipid droplets into fatty acids. Lipid droplets are coated with perilipin (Plin) proteins and they need to be eliminated for the degradation of the lipids inside. Cytosolic Heat shock cognate 71 kDa protein (Hspa8) binds Plin2 and Plin3 on the lipid droplet surface. Subsequently, Prkaa2 binds and phosphorylates perilipins targeting them for lipophagy (S Kaushik et al. 2015, S Kaushik et al. 2016). The precise phosphorylation site(s) on Plins are unknown.

Literature References

PubMed ID	Title	Journal	Year
26902588	AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA Cuervo, AM, Kaushik, S	Autophagy	2016
25961502	Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis Cuervo, AM, Kaushik, S	Nat. Cell Biol.	2015