Cd19 is phosphorylated

Stable Identifier
R-MMU-9607042
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Cd19 is phosphorylated

In response to BCR activation, Cd19 in a stable complex with Vav1 (Fujimoto et al. 1999) is phosphorylated by Src kinases (Buhl and Cambier 1999, Xu et al. 2002, Ishiura et al. 2010), one of which may be Lyn (Fujimoto et al. 2000). Cd19 is required for activation of Btk, indicating that phosphoinositol 3,4,5-trisphosphate (PIP3) generated by phosphoinositide 3-kinase (Pi3k) bound to phosphorylated Cd19 recruits Btk to the plasma membrane (Buhl and Cambier 1999).

Literature References
PubMed ID Title Journal Year
12471124 The activation and subsequent regulatory roles of Lyn and CD19 after B cell receptor ligation are independent

Xu, Y, Beavitt, SJ, Harder, KW, Hibbs, ML, Tarlinton, DM

J Immunol 2002
10358152 CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation

Fujimoto, M, Poe, JC, Jansen, PJ, Sato, S, Tedder, TF

J. Immunol. 1999
20101619 Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation

Ishiura, N, Nakashima, H, Watanabe, R, Kuwano, Y, Adachi, T, Takahashi, Y, Tsubata, T, Okochi, H, Tamaki, K, Tedder, TF, Fujimoto, M

Eur. J. Immunol. 2010
10933394 CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification

Fujimoto, M, Fujimoto, Y, Poe, JC, Jansen, PJ, Lowell, CA, DeFranco, AL, Tedder, TF

Immunity 2000
10201980 Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase

Buhl, AM, Cambier, JC

J. Immunol. 1999
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Orthologous Events
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