Btk autophosphorylates

Stable Identifier
R-MMU-9607033
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Btk autophosphorylates

After phosphorylation on tyrosine-551 by Lyn or Syk, Btk autophosphorylates tyrosine-223 (Mahajan et al. 1995, Park et al. 1996).

Literature References
PubMed ID Title Journal Year
7565679 Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase

Fargnoli, J, Bolen, JB, Saouaf, SJ, Mahajan, S, Burkhardt, AL, Kut, SA

Mol. Cell. Biol. 1995
8630736 Regulation of Btk function by a major autophosphorylation site within the SH3 domain

Park, H, Turck, CW, Witte, ON, Kinet, JP, Scharenberg, AM, Tam, C, Wahl, MI, Rawlings, DJ, Afar, DE

Immunity 1996
Participants
Catalyst Activity

protein tyrosine kinase activity of p-Y551-Btk [cytosol]

Orthologous Events
Authored
Reviewed
Created
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