Sirt6 deacetylates histones at Notch1 and Notch4 gene promoters

Stable Identifier
R-MMU-9604841
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Sirt6 deacetylates histones at Notch1 and Notch4 gene promoters
Mouse Sirt6 deacetylates H3 histones on lysine residue 10 (removing the H3K9Ac epigenetic mark) at promoters of mouse Notch1 and Notch4 genes (Liu et al. 2017).
Literature References
PubMed ID Title Journal Year
28871079 Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

Zhang, C, Sun, Y, Su, H, Wang, X, Peng, J, Li, N, Zhang, Y, Zhen, J, Yi, F, Liang, K, Zhou, M, Wei, X, Gao, C, Liu, M, Wang, Z, Zhou, Z

Nat Commun 2017
Participants
Input
Output
Catalyst Activity

NAD-dependent histone deacetylase activity (H3-K9 specific) of Sirt6:Nucleosome(H3K9ac):Notch1,Notch4 gene [nucleoplasm]

Physical Entity
Sirt6:Nucleosome(H3K9ac):Notch1,Notch4 gene [nucleoplasm] (Mus musculus)
Activity
NAD-dependent histone deacetylase activity (H3-K9 specific) (GO:0046969)
Orthologous Events
SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-05)
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