Adam10 cleaves Notch4

Stable Identifier
R-MMU-9604278
Type
Reaction [omitted]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Adam10 cleaves Notch4
Mouse endothelial cell-targeted knockout of both Notch1 and Notch4 is needed to recapitulate vasculature defects seen upon endothelial cell-targeted Adam10 knockout. Based on this and on sequence similarity between Notch4 and other Notch family members, it is highly likely that Adam10 cleaves ligand-activated Notch4, releasing the membrane-bound NEXT4 fragment (Alabi et al. 2016).
Literature References
PubMed ID Title Journal Year
27354212 ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds

Blobel, CP, Alabi, RO, Haxaire, C, Glomski, K, Monette, S, Weskamp, G

Circ. Res. 2016
Participants
Input
Output
Catalyst Activity

metalloendopeptidase activity of Adam10 [plasma membrane]

Physical Entity
Adam10 [plasma membrane] (Mus musculus)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
ADAM10 cleaves NOTCH4 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-02)
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