Reactome | Interaction of MEKK1 with TRAF6

Interaction of MEKK1 with TRAF6

Stable Identifier

R-MMU-933534

Type

Reaction [binding]

Species

Mus musculus

Compartment

cytosol

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

TRAF6 requires MEKK1 (MAP3K1) to activate NF-kB and MEKK1 may interact with TRAF6, which in turn contributes to the activation of IKK and MAPKK, leading to the activation of NF-kB and AP-1. (Yoshida et al)

Literature References

PubMed ID	Title	Journal	Year
18984593	TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway Kobayashi, T, Kawai, T, Yoshioka, T, Yoshida, H, Takaesu, G, Yoshida, R, Yoshimura, A, Choi, Y, Akira, S, Okamoto, F	J Biol Chem	2008