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holoTF:TFRC dimer [plasma membrane]
Stable Identifier
R-MMU-917834
Type
Complex
Species
Mus musculus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Mus musculus)
Iron uptake and transport (Mus musculus)
Transferrin endocytosis and recycling (Mus musculus)
TFRC dimer binds 2xholoTF (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
Vesicle-mediated transport (Mus musculus)
Membrane Trafficking (Mus musculus)
Clathrin-mediated endocytosis (Mus musculus)
BAR domain proteins recruit dynamin (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
CLASP proteins:cargo [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
CLASP proteins:cargo [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
CLASP proteins:cargo [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
CLASP proteins:cargo [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
AP-2 directly binds some endocytic cargo (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
Clathrin recruits PIK3C2A (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
CLASP proteins:cargo [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
CLASP proteins:cargo [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
CLASP proteins:cargo [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
CLASP proteins:cargo [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
CLASP proteins:cargo [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
CLASP proteins:cargo [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
CLASP proteins:cargo [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
CLASP proteins:cargo [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
CLASP proteins:cargo [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
CLASP proteins:cargo [plasma membrane] (Mus musculus)
AP-2:cargo [plasma membrane] (Mus musculus)
AP-2 cargo [plasma membrane] (Mus musculus)
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
holoTF:TFRC dimer [plasma membrane] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
holoTF [extracellular region]
(Mus musculus)
TFRC dimer [plasma membrane]
(Mus musculus)
Participates
as a member of
AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
as an output of
TFRC dimer binds 2xholoTF (Mus musculus)
as an input of
holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Mus musculus)
Inferred From
holoTF:TFRC dimer [plasma membrane]
(Homo sapiens)
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