Shp2 can recruit Grb2

Stable Identifier
R-MMU-914067
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Shp2 can recruit Grb2

SHP2 can associate with GRB2 (Stein-Gerlach et al. 1995). IL-3 induces the phosphorylation of SHP2 and its association with GRB2 (Welham et al. 1994). SHP2 may act as a scaffold protein to recruit other signaling molecules, e.g. SHP2 was reported to link GRB2 to the receptor tyrosine kinase c-kit (Tauchi et al. 1994).

Literature References
PubMed ID Title Journal Year
7559570 Protein-tyrosine phosphatase 1D modulates its own state of tyrosine phosphorylation

Stein-Gerlach, M, Kharitonenkov, A, Vogel, W, Ali, S, Ullrich, A

J Biol Chem 1995
7522233 Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase

Welham, MJ, Dechert, U, Leslie, KB, Jirik, F, Schrader, JW

J Biol Chem 1994
Participants
Orthologous Events
Authored
Reviewed
Created