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About
What is Reactome ?
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IL5 homodimer [extracellular region]
Stable Identifier
R-MMU-913383
Type
Complex
Species
Mus musculus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-2 family signaling (Mus musculus)
Interleukin receptor SHC signaling (Mus musculus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Mus musculus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Phosphorylated SHC1 recruits SHIP (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Mus musculus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
14-3-3 zeta binding allows recruitment of PI3K (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Activation of STAT5a/b by JAK2 (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
IL3RB is phosphorylated on Ser-585 (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin receptor SHC signaling (Mus musculus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Mus musculus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Phosphorylated SHC1 recruits SHIP (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Mus musculus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin-5 is a homodimer (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin-5 receptor alpha subunit binds Interleukin-5 (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
JAK2 is phosphorylated, activated (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
SHP1 and SHP2 bind the common beta chain (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593)-Bc [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
STAT5 is recruited by JAK2 (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
The receptor is activated (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Tyrosine kinases phosphorylate the receptor (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
p-S585-IL3RB binds 14-3-3 proteins (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
p-STAT5 dissociates from the receptor complex (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS GEFs promote RAS nucleotide exchange (Mus musculus)
RAS GEFs [plasma membrane] (Mus musculus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Mus musculus)
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
IL5 homodimer [extracellular region] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
Il5 [extracellular region]
(Mus musculus)
Participates
as an input of
Interleukin-5 receptor alpha subunit binds Interleukin-5 (Mus musculus)
as an output of
Interleukin-5 is a homodimer (Mus musculus)
as a component of
IL5 homodimer:IL5RA [plasma membrane] (Mus musculus)
Inferred From
IL5 homodimer [extracellular region]
(Homo sapiens)
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