Reactome | ATP6V1B1 [cytosol]

ATP6V1B1 [cytosol]

Stable Identifier

R-MMU-912604

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q91YH6

Locations in the PathwayBrowser

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Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to starvation (Mus musculus)
    - Amino acids regulate mTORC1 (Mus musculus)
      - RRAGA,B exchanges GDP for GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
      - RRAGA,B hydrolyzes GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
      - RRAGC,D exchanges GTP for GDP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
      - RRAGC,D hydrolyzes GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
      - mTORC1 binds RHEB:GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - ROS and RNS production in phagocytes (Mus musculus)
    - Intraphagosomal pH is lowered to 5 by V-ATPase (Mus musculus)
      - V-ATPase [phagocytic vesicle membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by Insulin receptor (Mus musculus)
    - Insulin receptor recycling (Mus musculus)
      - ATP6AP1 binds V-ATPase (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
      - Endosome acidification (Mus musculus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)

Transport of small molecules (Mus musculus)

- Ion channel transport (Mus musculus)
  - ATP6AP1 binds V-ATPase (Mus musculus)
    - V-ATPase [endosome membrane] (Mus musculus)
      - ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
    - V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
      - V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
- Iron uptake and transport (Mus musculus)
  - Transferrin endocytosis and recycling (Mus musculus)
    - ATP6AP1 binds V-ATPase (Mus musculus)
      - V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)
    - Acidification of Tf:TfR1 containing endosome (Mus musculus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q91YH6

Reference Genes

BioGPS Gene:110935

ENSEMBL:ENSMUSG00000006269

ENSEMBL:ENSMUSG00000006269.8

KEGG Gene (Mus musculus):110935

Monarch:110935

NCBI Gene:110935

UCSC:Q91YH6

Reference Transcript

RefSeq:NM_134157.2

Other Identifiers

10539449

110935

111602_at

1419373_at

17460107

4348513

4351475

4440115

4559535

4566477

4610978

4680330

4767081

4841193

5008576

5033710

5145203

5253077

5493044

5494602

5518055

A_52_P169982

GE128306

GO:0000166

GO:0000221

GO:0001503

GO:0003014

GO:0003091

GO:0003096

GO:0005215

GO:0005524

GO:0005737

GO:0005773

GO:0005829

GO:0005886

GO:0005902

GO:0006629

GO:0006693

GO:0006811

GO:0006885

GO:0007035

GO:0007605

GO:0008021

GO:0010468

GO:0015078

GO:0016020

GO:0016192

GO:0016323

GO:0016324

GO:0016328

GO:0016471

GO:0030534

GO:0031410

GO:0033180

GO:0035812

GO:0042048

GO:0043226

GO:0044877

GO:0045851

GO:0046034

GO:0046961

GO:0050877

GO:0055064

GO:0055065

GO:0055074

GO:0055075

GO:0055085

GO:0055086

GO:0065003

GO:0070072

GO:0097254

GO:0097401

GO:0098850

GO:0140657

GO:1901135

GO:1902600

ILMN_2718176

ILMN_2879910

mMC023076

Participates

as a member of

ATP6V1B [cytosol] (Mus musculus)

Inferred From

ATP6V1B1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_598918.1

Ensembl

ENSMUST00000006431, ENSMUSG00000006269, ENSMUSP00000006431

MGI

103285

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