Reactome | TOP3A [nucleoplasm]

TOP3A [nucleoplasm]

Stable Identifier

R-MMU-912452

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

O70157

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G2/M Checkpoints (Mus musculus)
    - G2/M DNA damage checkpoint (Mus musculus)
      - ATR phosphorylates TP53 (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)

DNA Repair (Mus musculus)

- DNA Double-Strand Break Repair (Mus musculus)
  - Homology Directed Repair (Mus musculus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
      - HDR through Homologous Recombination (HRR) (Mus musculus)
        
        D-loop extension by DNA polymerases (Mus musculus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        Homologous DNA Pairing and Strand Exchange (Mus musculus)
        
        CX3 complex binds D-loop structures (Mus musculus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        D-loop formation mediated by PALB2, BRCA2 and RAD51 (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Mus musculus)
        
        BCDX2 complex stabilizes RAD51 filament (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        Resolution of D-Loop Structures (Mus musculus)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Mus musculus)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Mus musculus)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        Ligation of DNA and formation of Holliday structures following repair synthesis (Mus musculus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        MUS81:EME1,EME2 cleaves D-loop (Mus musculus)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        SPIDR binds BLM:TOP3A:RMI1:RMI2 (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2:SPIDR [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
      - HDR through Single Strand Annealing (SSA) (Mus musculus)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        ERCC1:XPF cleaves flaps generated by SSA (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
      - Processing of DNA double-strand break ends (Mus musculus)
        
        ATR activation at DNA DSBs (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        ATR phosphorylates RPA2 (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        Activation of CHEK1 at resected DNA DSBs (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        Association of RPA complexes with ssDNA at resected DNA DSBs (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        Binding of ATR:ATRIP to RPA at resected DNA DSBs (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        CHEK1 is recruited to resected DNA DSBs (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Mus musculus)
        
        3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        Long-range resection of DNA DSBs by EXO1 or DNA2 (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)
        
        3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - Regulation of TP53 Activity (Mus musculus)
        
        Regulation of TP53 Activity through Phosphorylation (Mus musculus)
        
        ATR phosphorylates TP53 (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        TOP3A [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:O70157 Top3a

Gene Names

Top3a, Top3

Chain

chain:1-1003

Reference Genes

BioGPS Gene:21975 Top3a

ENSEMBL:ENSMUSG00000002814.16 Top3a

KEGG Gene (Mus musculus):21975 Top3a

Monarch:21975 Top3a

NCBI Gene:21975 Top3a

UCSC:O70157 Top3a

Reference Transcript

RefSeq:NM_009410.2 Top3a

Other Identifiers

10386582

1418597_at

17263642

21975

4427446

4442876

4452728

4459410

4509874

4529648

4539380

4564116

4589425

4654339

4673254

4695947

4829192

4848246

4876028

5031907

5141412

5158195

5293175

5398137

5405713

5485544

5497957

5519392

5542957

5590694

94124_at

A_51_P203451

A_55_P1953578

GE33832

GO:0000724

GO:0003677

GO:0003697

GO:0003824

GO:0003916

GO:0003917

GO:0005634

GO:0005654

GO:0005694

GO:0005739

GO:0005759

GO:0006265

GO:0006281

GO:0006310

GO:0007005

GO:0007059

GO:0008270

GO:0016605

GO:0016853

GO:0031422

GO:0032042

GO:0043226

GO:0046872

GO:0051304

GO:0071139

GO:0140097

ILMN_1249579

mMR027960

Participates

as a component of

BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)

Other forms of this molecule

DNA topoisomerase 3-alpha [nucleoplasm]

Inferred From

TOP3A [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_033436.1

Ensembl

ENSMUSP00000002891, ENSMUST00000002891, ENSMUSG00000002814

PRO

O70157

MGI

1197527

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