Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1 binds Grb2-1:Sos1

Stable Identifier
R-MMU-9029146
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1 binds Grb2-1:Sos1
Phosphorylated Shc1 in the Epor complex serves as a scaffold to bind Grb2 (Cutler et al. 1993, Damen et al. 1993, Miura et al. 1994). Grb2 may be pre-associated with Vav1 or Sos1 (Barber et al. 1997), which are guanine nucleotide exchange factors for Ras, or with Cbl, an ubiquitin ligase. Shc1 and Grb2 may also be recruited by interacting with Ship1 bound to Epor (Mason et al. 2000)
Literature References
PubMed ID Title Journal Year
8978277 Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells

Barber, DL, Corless, CN, Xia, K, Roberts, TM, D'Andrea, AD

Blood 1997
8400282 Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

Damen, JE, Liu, L, Cutler, RL, Krystal, G

Blood 1993
10660611 The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor

Mason, JM, Beattie, BK, Liu, Q, Dumont, DJ, Barber, DL

J. Biol. Chem. 2000
7961995 Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor

Miura, Y, Miura, O, Ihle, JN, Aoki, N

J. Biol. Chem. 1994
7691810 Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells

Cutler, RL, Liu, L, Damen, JE, Krystal, G

J. Biol. Chem. 1993
Participants
Input
Output
Orthologous Events
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 (Homo sapiens)
Authored
May, B  (2017-11-11)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-11-14)
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