Mecp2 binds Htt

Stable Identifier
R-MMU-9023599
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Mecp2 binds Htt

Mouse Mecp2 binds to mouse Htt (Huntingtin), predominantly in the nucleus. Binding is increased when mouse Htt is engineered to contain expanded human polyglutamine tract (polyQ), to mimic the mutant Htt (McFarland et al. 2013).

Literature References
PubMed ID Title Journal Year
24105466 MeCP2: a novel Huntingtin interactor

McFarland, KN, Huizenga, MN, Darnell, SB, Sangrey, GR, Berezovska, O, Cha, JH, Outeiro, TF, Sadri-Vakili, G

Hum. Mol. Genet. 2014
Participants
Orthologous Events
Authored
Reviewed
Created
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