Reactome | Insulin secretory granules dock at the plasma membrane

Insulin secretory granules dock at the plasma membrane

Stable Identifier

R-MMU-9023194

Type

Reaction [omitted]

Species

Mus musculus

Compartment

cytosol

ReviewStatus

5/5

General

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Insulin secretory granules dock at the plasma membrane

Insulin-containing secretory granules are bound to Myosin Va via Rab27a in a complex of uncertain composition. Mysosin Va moves along the cortical actin network (actin at the periphery of the cytoplasm), carrying the granules to the inner surface of the plasma membrane.

Literature References

PubMed ID	Title	Journal	Year
18801842	Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic beta-cells Merrins, MJ, Stuenkel, EL	J Physiol	2008
22993210	MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway Regazzi, R, Molnár, E, Váradi, A, Hayward, K, Lajus, S, Rajatileka, S, Brozzi, F, Diraison, F	Mol. Biol. Cell	2012
11865063	The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules Hosaka, M, Aoki, T, Torii, S, Takata, K, Yokota, H, Izumi, T, Yi, Z, Takeuchi, T, Zhao, S	Mol Cell Biol	2002
17827149	MyRIP anchors protein kinase A to the exocyst complex Scott, JD, Hinke, SA, Pedroja, BS, Goehring, AS, Langeberg, LK	J Biol Chem	2007
15690086	Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation Kasai, H, Kasai, K, Takahashi, N, Mizutani, S, Gomi, H, Ohara-Imaizumi, M, Nagamatsu, S, Izumi, T, Kikuta, T, Zhao, S	J Clin Invest	2005
16714477	Insulin vesicle release: walk, kiss, pause ... then run Rutter, GA, Hill, EV	Physiology (Bethesda)	2006