Gad1 gene expression is stimulated by Mecp2

Stable Identifier
R-MMU-9022943
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Gad1 gene expression is stimulated by Mecp2
Mouse Mecp2 directly stimulates transcription of the mouse Gad1 (Gad67) gene, encoding glutamate decarboxylase 1, an enzyme involved in GABA synthesis (Chao et al. 2010).
Literature References
PubMed ID Title Journal Year
21068835 Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

Neul, JL, Chahrour, M, Xue, M, Samaco, RC, Noebels, JL, Zoghbi, HY, Rubenstein, JL, Chen, H, Lu, HC, Yoo, J, Ekker, M, Heintz, N, Rosenmund, C, Gong, S, Chao, HT

Nature 2010
Participants
Input
Output
This event is regulated
Positively by
Regulator
Mecp2:Gad1 gene [nucleoplasm] (Mus musculus)
Active Unit
Mecp2 [nucleoplasm]
Orthologous Events
GAD1 gene expression is stimulated by MECP2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-26)
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