Mecp2 binds Dgcr8

Stable Identifier
R-MMU-9022302
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Mecp2 binds Dgcr8
Mouse Mecp2, phosphorylated at serine residue S80, binds to mouse Dgcr8. The interaction involves the C-terminus of Mecp2 and the RNA binding domain-containing C-terminus of Dgcr8 (Cheng et al. 2014). In addition to Dgcr8, Mecp2 was reported to also bind other components of the Drosha complex (Tsujimura et al. 2015).
Literature References
PubMed ID Title Journal Year
24636259 MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex

Xu, W, Zhou, WH, Wang, Z, Liao, Q, Qiu, Z, Zhu, Y, Cheng, TL

Dev. Cell 2014
26344767 miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes

Nakahata, Y, Itoh, M, Irie, K, Takamori, S, Nakashima, K, Egashira, Y, Uesaka, M, Imamura, T, Tsujimura, K, Nakashima, H, Fukao, Y, Yamashita, Y, Fujiwara, M, Abe, T

Cell Rep 2015
Participants
Input
Output
Orthologous Events
MECP2 binds DGCR8 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-22)
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