Transcription of Robo3.2 mRNA

Stable Identifier
R-MMU-9014598
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Transcription of Robo3.2 mRNA
Robo3.2 is a transcript variant of mouse Robo3 mRNA produced by alternative splicing. Compared to Robo3.1 mRNA, Robo3.2 mRNA retains the intronic sequence between exons 26 and 27, which creates a premature stop codon. Robo3.1 mRNA is expressed in the pre-crossing and crossing commissural axons, while Robo3.2 mRNA is expressed after midline crossing and thought to block midline re-crossing (Chen et al. 2008).
Literature References
PubMed ID Title Journal Year
18466743 Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion

Gore, BB, Ma, L, Long, H, Tessier-Lavigne, M, Chen, Z

Neuron 2008
Participants
Input
Output
Orthologous Events
Transcription of ROBO3.2 mRNA (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-26)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-08-02)
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