phospho-Epor:phospho-Jak2:Lyn:Irs2 binds Stat5

Stable Identifier
R-MMU-9012656
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
phospho-Epor:phospho-Jak2:Lyn:Irs2 binds Stat5
Stat5 (Stat5a or Stat5b) binds the phosphorylated cytoplasmic domain of Epor via phosphotyrosine-343 and phosphotyrosine-479 of Epor (Chin et al. 1996, Gobert et al. 1996, Sawyer and Penta 1996, Damen et al. 1997, Iwatsuki et al. 1997, Barber et al. 2001, Bittorf et al. 2000).
Literature References
PubMed ID Title Journal Year
8665851 Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation

Groner, B, Mayeux, P, Lacombe, C, Gisselbrecht, S, Gobert, S, Dusanter-Fourt, I, Pallard, C, Muller, O, Chrétien, S, Gouilleux, F

EMBO J. 1996
8977232 Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3

Chin, H, Ihle, JN, Kamiyama, R, Miura, O, Nakamura, N, Miyasaka, N

Blood 1996
10676844 Activation of STAT5 during EPO-directed suppression of apoptosis

Jaster, R, Bittorf, T, Lüdtke, B, Brock, J, Büchse, T, Seiler, J

Cell. Signal. 2000
11290583 A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation

Neel, BG, D'Andrea, AD, Yoakim, M, Beattie, BK, Barber, DL, Mason, JM, Nguyen, MH, Frank, DA

Blood 2001
9209412 The role of erythropoietin receptor tyrosine phosphorylation in erythropoietin-induced proliferation

Krosl, J, Miyajima, A, Wakao, H, Humphries, RK, Rosten, P, Majerus, PW, Liu, L, Krystal, G, Jefferson, AB, Damen, JE

Leukemia 1997
8943308 Association of JAK2 and STAT5 with erythropoietin receptors. Role of receptor phosphorylation in erythropoietin signal transduction

Penta, K, Sawyer, ST

J. Biol. Chem. 1996
9079629 STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line

Ohtsubo, M, Endo, T, Yoshimura, A, Misawa, H, Matsumoto, A, Iwatsuki, K, Mori, KJ, Yokouchi, M

J. Biol. Chem. 1997
Participants
Input
Output
Orthologous Events
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 (Homo sapiens)
Authored
May, B  (2017-06-17)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-07-17)
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