Robo2 gene expression is stimulated by Hoxa2 and inhibited by Lhx2

Stable Identifier
R-MMU-9010527
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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Robo2 gene expression is stimulated by Hoxa2 and inhibited by Lhx2

In mice, the homeobox transcription factor Hoxa2, which directly binds to an evolutionarily conserved site in the second intron of the Robo2 gene, is needed for the maintenance of Robo2 expression during pontine neuron migration (Geisen et al. 2008).

Mouse Lhx2, a LIM-homeodomain transcription factor, directly represses transcription of the Robo2 gene by binding to evolutionarily conserved Lhx2 binding sites about 50 kb downstream from the Robo2 gene transcription start site. Lhx2 is involved in thalamocortical axon guidance (Marcos-Mondejar et al. 2012).

Literature References
PubMed ID Title Journal Year
22457488 The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors

Marcos-Mondéjar, P, Peregrín, S, Li, JY, Carlsson, L, Tole, S, López-Bendito, G

J. Neurosci. 2012
18547144 Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling

Geisen, MJ, Di Meglio, T, Pasqualetti, M, Ducret, S, Brunet, JF, Chédotal, A, Rijli, FM

PLoS Biol. 2008
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