Robo2 gene expression is stimulated by Hoxa2 and inhibited by Lhx2

Stable Identifier
R-MMU-9010527
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
General
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Robo2 gene expression is stimulated by Hoxa2 and inhibited by Lhx2
In mice, the homeobox transcription factor Hoxa2, which directly binds to an evolutionarily conserved site in the second intron of the Robo2 gene, is needed for the maintenance of Robo2 expression during pontine neuron migration (Geisen et al. 2008).

Mouse Lhx2, a LIM-homeodomain transcription factor, directly represses transcription of the Robo2 gene by binding to evolutionarily conserved Lhx2 binding sites about 50 kb downstream from the Robo2 gene transcription start site. Lhx2 is involved in thalamocortical axon guidance (Marcos-Mondejar et al. 2012).

Literature References
PubMed ID Title Journal Year
18547144 Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling

Brunet, JF, Rijli, FM, Pasqualetti, M, Geisen, MJ, Chédotal, A, Di Meglio, T, Ducret, S

PLoS Biol. 2008
22457488 The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors

Carlsson, L, Li, JY, López-Bendito, G, Marcos-Mondéjar, P, Peregrín, S, Tole, S

J. Neurosci. 2012
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Lhx2:Robo2 gene [nucleoplasm] (Mus musculus)
Active Unit
Lhx2 [nucleoplasm]
Positively by
Regulator
Hoxa2:Robo2 gene [nucleoplasm] (Mus musculus)
Active Unit
Hoxa2 [nucleoplasm]
Orthologous Events
ROBO2 gene transcription is stimulated by HOXA2 and inhibited by LHX2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-23)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-06-27)
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