Proteasome degrades polyubiquitinated Runx2

Stable Identifier
R-MMU-9008717
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Proteasome degrades polyubiquitinated Runx2

In mouse cells, Runx2 polyubiquitinated by Fbxw7alpha is degraded by the proteasome (Kumar et al. 2015).

Literature References
PubMed ID Title Journal Year
26542806 E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation

Kumar, Y, Kapoor, I, Khan, K, Thacker, G, Khan, MP, Shukla, N, Kanaujiya, JK, Sanyal, S, Chattopadhyay, N, Trivedi, AK

J. Biol. Chem. 2015
Participants
Catalyst Activity

endopeptidase activity of Proteasome [nucleoplasm]

Orthologous Events
Authored
Reviewed
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