Bglap gene expression is negatively regulated by Znf521

Stable Identifier
R-MMU-9008164
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Bglap gene expression is negatively regulated by Znf521
In mouse osteoblasts, transcription from the Bglap (Osteocalcin) gene promoter is inhibited by Znf521 (Zfp521) and Hdac3, which form a complex with Runx2 (Hesse et al. 2010).
Literature References
PubMed ID Title Journal Year
21173110 Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity

Hesse, E, Saito, H, Kiviranta, R, Correa, D, Yamana, K, Neff, L, Toben, D, Duda, G, Atfi, A, Geoffroy, V, Horne, WC, Baron, R

J. Cell Biol. 2010
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Runx2:Znf521:Hdac3 [nucleoplasm] (Mus musculus)
Active Unit
Znf521 [nucleoplasm]
Hdac3 [nucleoplasm]
Orthologous Events
BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-07)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-07)
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