Dlx5,(Dlx6) binds Runx2 gene promoter

Stable Identifier
R-MMU-9007731
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dlx5,(Dlx6) binds Runx2 gene promoter
Mouse Dlx5, activated in response to Bmp2 signaling, binds three sites in the mouse Runx2 gene promoter (Lee et al. 2005). Based on several studies, Dlx6 is suggested to be redundant with Dlx5 in the regulation of Runx2 expression (Robledo et al. 2002, Holleville et al. 2007, Barron et al. 2011) and is therefore shown as a candidate transcriptional regulator of Runx2.
Literature References
PubMed ID Title Journal Year
12000792 The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development

Li, X, Robledo, RF, Rajan, L, Lufkin, T

Genes Dev. 2002
16115867 Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter

Choi, KY, Lee, MH, Cho, JY, Wozney, JM, Hwang, YS, Kim, YJ, Choi, JY, Bae, SC, Ryoo, HM, Chi, XZ, Kim, BG, Kim, JI, Yoon, WJ

J. Biol. Chem. 2005
Participants
Input
Output
This event is regulated
Positively by
Regulator
Bmp2 dimer [extracellular region] (Mus musculus)
Orthologous Events
DLX5,(DLX6) binds RUNX2 gene promoter (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-02)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-02)
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