Pvalb gene expression is repressed by Mecp2

Stable Identifier
R-MMU-9006511
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Pvalb gene expression is repressed by Mecp2

Binding of mouse Mecp2 to the promoter of the mouse Pvalb gene represses Pvalb transcription. Pvalb is overexpressed in visual cortical neurons of Mecp2 mice, which is thought to contribute to visual regression (Durand et al. 2012).

Literature References
PubMed ID Title Journal Year
23259945 NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2

Durand, S, Patrizi, A, Quast, KB, Hachigian, L, Pavlyuk, R, Saxena, A, Carninci, P, Hensch, TK, Fagiolini, M

Neuron 2012
Participants
This event is regulated
Orthologous Events
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