Runx2 gene transcription is repressed by Nkx3-2 and Msx2, and activated by Dlx5,(Dlx6)

Stable Identifier
R-MMU-8985328
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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Runx2 gene transcription is repressed by Nkx3-2 and Msx2, and activated by Dlx5,(Dlx6)

In mouse, binding of the transcriptional repressor Nkx3-2 (Bapx1) to the distal (P1) Runx2 gene promoter represses Runx2 transcription (Lengner et al. 2005, Provot et al. 2006). Runx2-P1 isoform can repress its own transcription by binding to evolutionarily conserved Runx2 response elements in the distal P1 promoter (Drissi et al. 2000). Binding of the transcription factor Dlx5, activated by Bmp2 signaling, to the P1 promoter of Runx2 activates Runx2 transcription. Msx2 can antagonize Dlx5 by binding to Dlx5 binding sites in the Runx2 promoter and repressing Runx2 transcription (Lee et al. 2005). Dlx6 is suggested to act redundantly with Dlx5 in the activation or Runx2 expression (Robledo et al. 2002, Holleville et al. 2007, Barron et al. 2011).

Literature References
PubMed ID Title Journal Year
15703179 Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation

van Wijnen, AJ, Lengner, CJ, Lian, JB, Stein, JL, Stein, GS, Lepper, C, Hassan, MQ, Serra, RW

J. Biol. Chem. 2005
12000792 The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development

Li, X, Robledo, RF, Rajan, L, Lufkin, T

Genes Dev. 2002
10911365 Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene

Jones, S, Luc, Q, Stein, JL, Stein, GS, Choi, JY, Neil, JC, Hu, M, Van Wijnen, AJ, Terry, A, Drissi, H, Shakoori, R, Chuva De Sousa Lopes, S, Lian, JB

J. Cell. Physiol. 2000
16115867 Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter

Choi, KY, Lee, MH, Cho, JY, Wozney, JM, Hwang, YS, Kim, YJ, Choi, JY, Bae, SC, Ryoo, HM, Chi, XZ, Kim, BG, Kim, JI, Yoon, WJ

J. Biol. Chem. 2005
16421188 Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation

Lassar, AB, Kim, DW, Kronenberg, HM, Kempf, H, Chyung, J, Murtaugh, LC, Chung, UI, Provot, S

Development 2006
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