Experiments performed on mouse fibroblasts, including both NIH-3T3 cell line and embryonic fibroblasts, have shown that in G0 and early G1 phase p130 (Rbl2) and p107 (Rbl1), respectively, form a complex with the histone deacetylase Hdac1 and directly repress transcription of the Ccna2 gene (Rayman et al. 2002).
Rayman, JB, Takahashi, Y, Indjeian, VB, Dannenberg, JH, Catchpole, S, Watson, RJ, te Riele, H, Dynlacht, BD
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