Reactome | Mybl2 gene expression is inhibited by Rbl1 or Rbl2 in complex with Hdac1

Mybl2 gene expression is inhibited by Rbl1 or Rbl2 in complex with Hdac1

Stable Identifier

R-MMU-8978997

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm

ReviewStatus

5/5

General

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Mybl2 gene expression is inhibited by Rbl1 or Rbl2 in complex with Hdac1

Experiments performed on mouse fibroblasts, including both NIH-3T3 cell line and embryonic fibroblasts, have shown that in G0 and early G1 phase p130 (Rbl2) and p107 (Rbl1) form a complex with the histone deacetylase Hdac1 and directly repress transcription of the Mybl2 gene (Rayman et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11959842	E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex Catchpole, S, Dynlacht, BD, te Riele, H, Dannenberg, JH, Watson, RJ, Rayman, JB, Indjeian, VB, Takahashi, Y	Genes Dev	2002