Reactome | Gnai2 [plasma membrane]

Gnai2 [plasma membrane]

Stable Identifier

R-MMU-8964336

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Guanine nucleotide-binding protein G, GNAI2_MOUSE

Locations in the PathwayBrowser

Expand all

Hemostasis (Mus musculus)

- Platelet activation, signaling and aggregation (Mus musculus)
  - Signal amplification (Mus musculus)
    - ADP signalling through P2Y purinoceptor 12 (Mus musculus)
      - Activated P2Y purinoceptor 12 binds G-protein Gi (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai2 [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai2 [plasma membrane] (Mus musculus)
      - Dissociation of the P2Y purinoceptor 12:Gi complex (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai2 [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai2 [plasma membrane] (Mus musculus)
      - Gi activation by P2Y purinoceptor 12 (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai2 [plasma membrane] (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai2 [plasma membrane] (Mus musculus)

Neuronal System (Mus musculus)

- Transmission across Chemical Synapses (Mus musculus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Mus musculus)
    - GABA receptor activation (Mus musculus)
      - GABA B receptor activation (Mus musculus)
        
        Activation of GABAB receptors (Mus musculus)
        
        Adenylate cyclase inhibitory pathway (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai2 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai2 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai2 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai2 [plasma membrane] (Mus musculus)
        
        Dissociation of the Gi alpha:G olf complex (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai2 [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai2 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai2 [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai2 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P08752 Gnai2

Gene Names

Gnai2, Gnai-2

Chain

initiator methionine:, chain:2-355

Reference Genes

BioGPS Gene:14678 Gnai2

ENSEMBL:ENSMUSG00000032562.14 Gnai2

KEGG Gene (Mus musculus):14678 Gnai2

Monarch:14678 Gnai2

NCBI Gene:14678 Gnai2

UCSC:P08752 Gnai2

Reference Transcript

Other Identifiers

10596704

1419449_a_at

1435652_a_at

14678

17530955

4306183

4370773

4413758

4415282

4446964

4470628

4532420

4627487

4838280

4936936

4945882

4952263

4982993

5490076

5508084

5570974

99596_f_at

99597_at

99598_g_at

A_51_P432484

A_55_P2004137

GE34494

GO:0000166

GO:0001664

GO:0001973

GO:0003013

GO:0003014

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005834

GO:0005856

GO:0005886

GO:0007049

GO:0007165

GO:0007186

GO:0007188

GO:0007189

GO:0007193

GO:0007213

GO:0007214

GO:0008283

GO:0008284

GO:0012501

GO:0016020

GO:0016192

GO:0016787

GO:0019001

GO:0023052

GO:0030335

GO:0030425

GO:0030496

GO:0031410

GO:0031683

GO:0032930

GO:0035810

GO:0043226

GO:0044297

GO:0045202

GO:0045955

GO:0046628

GO:0046872

GO:0048870

GO:0050805

GO:0051301

GO:0051924

GO:0070374

GO:0098992

GO:0140199

GO:1904707

GO:2000179

GO:2001234

ILMN_2418465

ILMN_2908855

M13963_f_at

Msa.22597.0_f_at

Msa.698.0_f_at

mMC006681

mMR030701

Participates

as a candidate of

G alpha (i,o) (candidates) [plasma membrane] (Mus musculus)

as a component of

G alpha (i):GTP [plasma membrane] (Mus musculus)

as a member of

G alpha (i) [plasma membrane] (Mus musculus)

Inferred From

GNAI2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_032164.2, XP_006511700.1

Ensembl

ENSMUST00000192615, ENSMUSG00000032562, ENSMUSP00000142326, ENSMUST00000055704, ENSMUSP00000057543

PRO

P08752

MGI

95772

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