Socs3 gene expression is inhibited by Runx1

Stable Identifier
R-MMU-8955856
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Socs3 gene expression is inhibited by Runx1
Based on studies in mouse keratinocytes, Runx1, presumably in complex with Cbfb, inhibits transcription of the Socs3 gene by binding to Runx response elements within the Socs3 gene locus (Scheitz et al. 2012).
Literature References
PubMed ID Title Journal Year
23034403 Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer

Lee, TS, Tumbar, T, McDermitt, DJ, Scheitz, CJ

EMBO J. 2012
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Runx1:Cbfb:Socs3 gene [nucleoplasm] (Mus musculus)
Active Unit
Runx1:Cbfb [nucleoplasm]
Orthologous Events
SOCS3 gene expression is inhibited by RUNX1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2017-01-13)
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